Charles & Louella Snyder Ocular Development, Disease & Regeneration Laboratory

Jeffrey M. Gross, PhD
Professor of Ophthalmology
E. Ronald Salvitti Chair in Ophthalmology Research
Director, Louis J. Fox Center for Vision Restoration
University of Pittsburgh School of Medicine

Lab Personnel

Krista Angileri (Graduate Student)
Natalie Gath (Graduate Student)
Nick Hanovice (Graduate Student)
Andrea Hartsock, PhD (Postdoctoral Research Associate)
Jiwoon Lee, PhD (Postdoctoral Research Associate)
Pawat Seritrakul (Graduate Student)

Research Interests

Our research focuses on vertebrate eye development, disease and regeneration utilizing the zebrafish as a model system. Combining forward genetic screens with reverse genetic and embryological manipulations we hope to understand the molecular, cellular and developmental events that regulate eye formation and visual function. Current areas of interest in the lab include studies focusing on the development and maintenance of the lens, retina, hyaloid vasculature and retinal pigmented epithelium of the eye, and elucidation of the molecular and cellular mechanisms that regulate ocular morphogenesis and regeneration Our research combines molecular, cellular, biochemical, transgenic and in vivo imaging techniques to address these questions. It is our hope that these studies will ultimately lead to a better understanding of visual system disorders such as macular degeneration, retinal degenerations, cataracts and ocular colobomata that often result in blindness in afflicted patients.

For more information, please visit:
Ocular Development, Disease and Regeneration Laboratory
Louis J. Fox Center for Vision Restoration

Select Recent Publications

  1. Hartsock A, Arnold V, Lee C and JM Gross “In Vivo Analysis of Hyaloid Vasculature Morphogenesis in Zebrafish: A role for the lens in maturation and maintenance of the hyaloid” – Developmental Biology – 394(2):327-39 (2014)
  2. Lee C, JB Wallingford and JM Gross – “Mutation in cluap1/qilin results in photoreceptor degeneration in zebrafish” – Investigative Ophthalmology and Visual Science – 55(7):4585-4592 (2014)
  3. Seritrakul P and JM Gross “Expression of the de novo DNA Methyltransferases (dnmt3-dnmt8) during zebrafish lens development” - Developmental Dynamics - Feb;243(2):350-6 (2014)
  4. Shine L, Kilty C, Gross JM, and B Kennedy “Vacuolar ATPases and their role in vision” in Retinal Degeneration 2013 (2014)
  5. Daly CMS, Willer J, Gregg RG and JM Gross “snow white, a zebrafish model of Hermansky-Pudlak Syndrome Type 5” Genetics Oct;195(2):481-94. (2013)
  6. Lee J, Lee BK and JM Gross “Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata” Human Molecular Genetics Sep 1;22(17):3568-82 (2013)
  7. Lee J, Cox BD, Daly C, Lee C, Nuckels RJ, Tittle RK, Uribe RA and JM Gross “An ENU mutagenesis screen in zebrafish for visual system mutants identifies a novel splice-acceptor site mutation in patched2 that results in colobomas” Investigative Ophthalmology and Visual Science – 53(13):8214-21 (2012)
  8. Hayes J, Hartsock A, Napier H, Link BA and JM Gross “Integrin alpha5/Fibronectin and Focal adhesion kinase are required for normal lens development in zebrafish” – Molecular Biology of the Cell – 23(24) 4725-38 (2012)
  9. Luo J, Uribe RA, Hayton S, Calinescu A, Gross JM, PF Hitchcock “Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina” Neural Development - 7(1):33 (2012)
  10. Uribe RA, Kwon T, Marcotte EM, JM Gross "Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis"– Developmental Biology, 371, 280-292 (2012)

Contact Information

Jeff Gross, PhD
412-383-7325
grossjm@pitt.edu
BST-3 2028, 3501 Fifth Avenue
Pittsburgh, PA 15213