Outflow Tract Engineering Laboratory

Nils Loewen, MD, PhD
Assistant Professor of Ophthalmology
University of Pittsburgh School of Medicine

Lab Personnel

Ralitsa Loewen, MD ( Postdoctoral Research Associate)
Pritha Roy Sangupta, MD ( Postdoctoral Research Associate)

We are actively recruiting postdocs, technicians and students.

Research Interests

Novel glaucoma outflow treatments; Gene therapy; Lentiviral vectors
Low pressure glaucoma; Suprachoroidal shunts

In his basic research, Dr. Loewen’s lab is focused on bioengineering of the ocular outflow system to lower eye pressure. He spearheaded gene therapy for glaucoma with lentiviral vectors. He developed a technique to permanently genetically modify the outflow tract of the eye, the site of the primary pathology in glaucoma. His present research is focused on using these tools to reverse engineer a working outflow tract with stem cells as a novel treatment of glaucoma.

Current Projects

Clinical Research

  • Comparison of Two Micro-Incisional Glaucoma Surgeries
    We are comparing two safer and faster glaucoma surgeries in early to advanced glaucoma.
     
  • Change of Aqueous Outflow Patterns Following Trabecular Meshwork Ablation
    We are measuring live how outflow changes in patients who underwent trabectome surgery.

Basic Research

  • Ocular outflow tract engineering using vector ablation and stem cells
    We are using gene therapy and stem cells to improve outflow and lower eye pressure in preclinical model systems.
     
  • In vivo mobilization of outflow tract stem cells
    We mobilize meshwork stem cells to regenerate the normal aqueous outflow

For more information, please follow visit: Outflow Tract Engineering

Contact Information

Nils Loewen, MD, PhD
412-647-2152
loewenna@upmc.edu
EEINS-8th Floor, 203 Lothrop Street
PIttsburgh PA, 15213