Ian A. Sigal, PhD

  • Assistant Professor of Ophthalmology
  • Ocular Biomechanics Laboratory
  • University of Pittsburgh School of Medicine

Academic Affiliation

Current

Assistant Professor, Department of Ophthalmology, University of Pittsburgh
Assistant Professor, Department of Bioengineering, University of Pittsburgh 
McGowan Institute for Regenerative Medicine

Previous

2009 -2010 Research associate. Devers Eye Institute, Portland, OR, USA
2007 - 2009 Post-doctoral fellow. Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA and Devers Eye Institute, Portland, OR, USA.
2006 - Post-doctoral fellow. Orthopaedic Biomechanics Laboratory, Sunnybrook Research Instititue, Toronto, ON, Canada.

Lab Personnel

Jonathan L. Grimm (grimmjl@upmc.edu) - Senior systems analyst

Education & Training

  • 2006 - Ph. D. Biomedical engineering collaborative program Department of Mechanical Engineering, University of Toronto, Toronto, ON, Canada.
  • 2001 - M. A. Sc. Aerospace engineering Institute for Aerospace Studies, University of Toronto, Toronto, ON, Canada.
  • 1999 - B. Sc. Physics Faculty of Sciences, Universidad Nacional Autónoma de México (UNAM), Mexico City, DF, Mexico.

Representative Publications

26 H. Yang, G. Williams, J.C. Downs, I.A. Sigal, M.D. Roberts, H. Thompson and C. F. Burgoyne. “Outward migration of the anterior and posterior lamina cribrosa insertions and early cupping in non-human primate experimental glaucoma”. Accepted by Invest Ophthalmol Vis Sci on 31 May 2011.

25 I.A. Sigal, “An applet to estimate the IOP-induced stress and strain within the optic nerve head”. Invest Ophthalmol Vis Sci, Epub 28 Apr 2011, PMID: 21527378.

24 L. Kagemann, G. Wollstein, H. Ishikawa, I.A. Sigal, L.S. Folio, J. Xu, H. Gong and J.S. Schuman, “3D Visualization of Aqueous Outflow Structures In-Situ in Humans”. Experimental Eye Research, Epub 15 Apr 2011 (Camras Special Issue). PMID: 21514296.

23 R. Norman, J.G. Flanagan, I.A. Sigal, S. Rausch, I. Tertinegg and C.R. Ethier. “Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma”. Experimental Eye Research, Epub 29 Sep 2010. PMID 20883693.

22 J.C. Downs, M.D. Roberts and I.A. Sigal, “Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism”, Experimental Eye Research, Epub 11 Aug 2010, PMID 20708001.

21 I.A. Sigal, H. Yang, M.D. Roberts, C.F. Burgoyne and J.C. Downs, “IOP-induced lamina cribrosa displacement and scleral canal expansion: an analysis of factor interactions using parameterized eye-specific models”, Invest Ophthalmol Vis Sci. 52(3):1896-1907, Mar 2011.

20 N.G. Strouthidis, B. Fortune, H. Yang, I.A. Sigal and C.F. Burgoyne, “Longitudinal change detected by spectral domain optical coherence tomography in the glaucomatous optic nerve head and peripapillary retina”, Invest Ophthalmol Vis Sci. 52(3):1206-19, Mar 2011.

19 H. Yang, H. Thompson, M.D. Roberts, I.A. Sigal, J.C. Downs and C. F. Burgoyne. “Deformation of the early glaucomatous monkey optic nerve head connective tissue following acute IOP elevation within 3-D histomorphometric reconstructions”, Invest Ophthalmol Vis Sci, 52(1):345-63, Jan 2011.

18 M.D. Roberts, I.A. Sigal, Y. Liang, C.F. Burgoyne and J. C. Downs. “Changes in the biomechanical response of the optic nerve head in early experimental glaucoma”, Invest Ophthalmol Vis Sci. 51(11):5675-5684, Nov 2010.

17 P.G. Sanfilippo, A. Cardini, I.A. Sigal, J. Ruddle, B.E. Chua, A.W. Hewitt, and D.A. Mackey. “A geometric morphometric assessment of the optic cup in glaucoma”, Experimental Eye Research, 91(3): 405-414, Sep 2010.

16 R. Norman, J.G. Flanagan, S. Rausch, I.A. Sigal, I. Tertinegg, A. Eilaghi, S. Portnoy, J. Sled and C.R. Ethier. “Dimensions of the human sclera: thickness measurement and regional changes with axial length”, Experimental Eye Research, 90(2): 277-284, Feb 2010.

15 I.A. Sigal and C.M. Whyne. “Mesh morphing and response surface analysis: quantifying sensitivity of vertebral mechanical behaviour”, Annals of Biomedical Engineering, 38(1):41-56, Jan 2010.

14 I.A. Sigal, H. Yang, M.D. Roberts and J.C. Downs. “Morphing methods to parameterize specimen-specific finite element model geometries”, Journal of Biomechanics, 43(2):254-262. 19, Jan 2010.

13 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier, “3D morphometry of the human optic nerve head”, Experimental Eye Research, 90(1):70-80, Jan 2010.

12 M.D. Roberts, Yi Liang, I.A. Sigal, J. Grimm, J. Reynaud, A. Bellezza, C.F. Burgoyne and J. C. Downs. “Correlation Between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes”, Invest Ophthalmol Vis Sci, 51(1):295-307, Jan 2010.

11 H. Yang, J.C. Downs, I.A. Sigal, M. Roberts, H. Thompson, C. F. Burgoyne. “Deformation of the normal monkey optic nerve head connective tissues following acute IOP elevation within 3-D histomorphometric reconstructions”, Invest Ophthalmol Vis Sci , 50(12): 5785-5789. Dec 2009.

10 I.A. Sigal. “Interactions between geometry and mechanical properties on the optic nerve head”, Invest Ophthalmol Vis Sci, 50(6): 2785-95. Jun 2009.

9 I.A. Sigal and C.R. Ethier. “Biomechanics of the optic nerve head”, Experimental Eye Research, 88(4):799-807, Apr 2009. 

8 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier. “Modeling individual-specific human optic nerve head biomechanics. Part II: Influence of material properties”, Biomech Model Mechanobiol, 
8(2):99-109, Apr 2009.

7 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier. “Modeling individual-specific human optic nerve head biomechanics. Part I: IOP-induced deformations and influence of geometry”, Biomech Model Mechanobiol, 8(2):85-98, Apr 2009.

6 I.A. Sigal, M.R. Hardisty and C.M. Whyne. “Mesh-morphing algorithms for specimen-specific finite element modeling”, J Biomech, 41(7):1381-1389, 2008.

5 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier. “Predicted extension, compression and shearing of optic nerve head tissues”, Experimental Eye Research, 85(3):312-322, Sep 2007.

4 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier, “Factors Influencing Human Optic Nerve Head Biomechanics”, Invest Ophthalmol Vis Sci, 46(11): 4189-4199, Nov 2005.

3 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier. “Reconstruction of Human Optic Nerve Heads for Finite Element Modeling”, Technology and Health Care: Official Journal of the European Society for Engineering and Medicine, 13(4): 313-329, Aug 2005.

2 I.A. Sigal, J.G. Flanagan, I. Tertinegg and C.R. Ethier. “Finite Element Modeling of Optic Nerve Head Biomechanics”, Invest Ophthalmol Vis Sci, 45(12): 4378-4387, Dec 2004.

1 I.L. Garzón, J.A. Reyes-Nava, J.I. Rodríguez-Hernández, I. Sigal, M.R. Beltrán and K. Michaelian. “Chirality in Bare and Passivated Gold Nanoclusters”, Phys. Rev. B 66(7), 073403, Aug 2002.

Research Interests

Ocular biomechanics
Simulation/modeling
Methods for multivariate analysis
Statistical shape analysis and geometric morphometrics

  • Ocular Biomechanics Laboratory