Robert L. Hendricks, PhD

  • Joseph F. Novak Endowed Chair
  • Professor and Vice-Chair for Research
  • Director, Ophthalmology & Visual Sciences Research Center
  • Departments of Ophthalmology, Immunology, Microbiology and Molecular Genetics and Biochemistry
  • University of Pittsburgh School of Medicine

Academic Affiliation

1998 – present: Professor and Vice-Chair for Research, Department of Ophthalmology, University of Pittsburgh,Pittsburgh, PA
1998 – present: Director, Ophthalmology and Visual Sciences Research Center, University of Pittsburgh, Pittsburgh, PA
1998 – present: Professor, Department of Molecular Genetics and Biochemistry
1998 – present: Member, University of Pittsburgh Cancer Institute
2002 – present: Professor, Department of Immunology, University of Pittsburgh,Pittsburgh, PA
2002 – present: Member, McGowan Institute for Regenerative Medicine, University of Pittsburgh,Pittsburgh, PA
2004 – present: Vice-Chair for Research, Department of Ophthalmology,University of Pittsburgh,Pittsburgh, PA

Education & Training

  • University of Illinois at Chicago, BS, Biology
  • University of Illinois at Chicago, MS, Microbiology
  • University of Illinois at Chicago, PhD, Immunology

Representative Publications

  1. St. Leger, A.J., Peters, B., Sidney, J., Sette, A., and Hendricks, R.L.:Defining the herpes simplex virus-specific CD8+ T cell repertoire in C57BL/6 mice. J. Immunol. 186: 3927-3933, 2011
  2. Frank, G. M., A. J. Lepisto, M. L. Freeman, B. S. Sheridan, T. L. Cherpes, and R. L. Hendricks. 2010. Early CD4(+) T cell help prevents partial CD8(+) T cell exhaustion and promotes maintenance of Herpes Simplex Virus 1 latency. J.Immunol. 184:277-286.
  3. Sheridan, B. S., T. L. Cherpes, J. Urban, P. Kalinski, and R. L. Hendricks. 2009. Reevaluating the CD8 T-cell response to herpes simplex virus type 1: involvement of CD8 T cells reactive to subdominant epitopes. J.Virol. 83:2237-2245. PMC 2643732
  4. Knickelbein, J. E., K. M. Khanna, M. B. Yee, C. J. Baty, P. R. Kinchington, and R. L. Hendricks. 2008. Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency. Science 322:268-271. PMC 2680315
  5. Cherpes, T. L., J. L. Busch, B. S. Sheridan, S. A. Harvey, and R. L. Hendricks. 2008. Medroxyprogesterone acetate inhibits CD8+ T cell viral-specific effector function and induces herpes simplex virus type 1 reactivation. J.Immunol. 181:969-975. PMC 2553693
  6. Freeman, M. L., B. S. Sheridan, R. H. Bonneau, and R. L. Hendricks. 2007. Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections. J.Immunol. 179:322-328. PMC 2367250 
  7. Sheridan, B. S., K. M. Khanna, G. M. Frank, and R. L. Hendricks. 2006. Latent virus influences the generation and maintenance of CD8+ T cell memory. J.Immunol. 177:8356-8364. PMC 2366996
  8. Decman, V., P. R. Kinchington, S. A. Harvey, and R. L. Hendricks. 2005. Gamma interferon can block herpes simplex virus type 1 reactivation from latency, even in the presence of late gene expression. J.Virol. 79:10339-10347. PMC 1182646
  9. Xu, M., A. J. Lepisto, and R. L. Hendricks. 2004. CD154 signaling regulates the Th1 response to herpes simplex virus-1 and inflammation in infected corneas. J.Immunol. 173:1232-1239.
  10. Khanna, K. M., R. H. Bonneau, P. R. Kinchington, and R. L. Hendricks. 2003. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18:593-603.

Research Interests

Viral Immunology Laboratory

Research Grants

P30 EY08098-20 Hendricks (PI & Module Director) 04/01/89-03/31/14
NIH/NEI 
“Core Grant for Vision Research”
The Core Grant will provide support for the following centralized research modules: Hybridoma/Tissue Culture; Molecular Biology; Electronic Shop; and Morphology & Image Analysis

T32 EY017271-01 Hendricks (PI) 05/01/08-04/30/13
NIH/NEI 
Interdisciplinary Visual Sciences Training Program
Provides support for graduate student and postdoctoral training in visual sciences

R01 EY10359-17 Hendricks (PI) 12/01/93-12/31/11
"Cytokines and Adhesion Molecules in HSV Keratitis"
The goal of this study is to examine the mechanisms of immunopathology in herpes simplex virus type 1 infected corneas.  

R01 EY05945-24 Hendricks (PI) 12/30/86-12/31/13
"Cytotoxic Lymphocytes and HSV-1 Corneal Lesions"
The goal of this study is to investigate the role of the immune system in controlling HSV-1 latency in sensory ganglia.