Xiangyun Wei, PhD

  • Associate Professor of Ophthalmology, Microbiology and Molecular Genetics, and Developmental Biology
  • Retinal Development Laboratory
  • University of Pittsburgh School of Medicine

Academic Affiliation

Department of Ophthalmology, 
Department of Microbiology and Molecular Genetics,

Department of Developmental Biology,
McGowan Institute for Regenerative Medicine 
University of Pittsburgh School of Medicine

Education & Training

  • University of Notre Dame Post-doc 2002-2003 Developmental biology.
  • Harvard Medical School/MEEI, Boston Post-doc 1998-2002 Developmental biology
  • SUNY/Buffalo Ph.D. 1993-1998 Cell Biology

Representative Publications

J. Zou, X. Wang, and X. Wei (2012) Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains. Developmental Cell. May 9. [Epub ahead of print]

J. Zou, X. Yang, and X. Wei (2010) Restricted Localization of Ponli, a Novel Zebrafish MAGUK-Family Protein, to the Inner Segment Interface Areas between Green, Red, and Blue Cones. Investigative Ophthalmology & Visual Science. 51 (3): 1738-1746.

X. Yang, J. Zou, D. Hyde, L. Davidson, and X. Wei (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. Journal of Neuroscience. 29:11426-11440.  

J. Zou, K. Lathrop, M. Sun, X. Wei (2008) Intact RPE maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish. Journal of Neuroscience. 28(50):13684 –13695.

X. Wei, C. Yan, Y. Luo, X. Shi, S. Nelson, and D. Hyde. (2004). The zebrafish Par-3 homolog is required for separation of the eye fields and retinal lamination, but not neuronal specification. Developmental Biology. 269:286-301.

X. Wei and J. Malicki. (2002). nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nature Genetics. 31, 150-157.

X. Wei, S. Somanathan, J. Samarabandu and R. Berezney. (1999). Three-dimensional visualization of transcription sites and their association with splicing factor-rich nuclear speckles. Journal of Cell Biology 146: 543-558.

X. Wei, J. Samarabandu, R.S. Devdhar, A. Siegel. R. Acharya, R. Berezney. (1998) Segregation of transcription and replication sites into higher order domains. Science. 281: 1502-1505.

Research Interests

Retinal Development Laboratory

Research Grants

NIH RO1 EY016099
PI: Xiangyun Wei
Sept 30, 2005 - Aug 31, 2013

Research to Prevent Blindness Lew R. Wasserman Merit Award
PI: Xiangyun Wei
2011