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28Wollstein.jpg Gadi Wollstein, MD
Associate Professor of Ophthalmology
Director, Ophthalmic Imaging Research Laboratories
University of Pittsburgh School of Medicine

203 Lothrop Street
Suite 834.1
Pittsburgh, PA 15213
Phone: 412-647-0325
Email: wollsteing@upmc.edu
Fax: 412-647-5119
Faculty Research Interests
Personal Web Page
 
bullet point  Research Interests
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Ophthalmic Imaging Research Laboratory

 
bullet point  Education
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Undergraduate: Hadassah and the Hebrew University Medical School, Jerusalem, Israel, BSc, Medical Science (Cum Lauda).

Graduate: Hadassah and the Hebrew University Medical School, Jerusalem, Israel, MD, Medicine.

Internship: Shaare Zedek Medical Center, Jerusalem, Israel.

Residency: Ophthalmology, Shaare Zedek Medical Center, Jerusalem, Israel.
Internal Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.

Fellowship: Moorfields Eye Hospital, London, UK.
New England Eye Center, Tuft Medical Center, Boston, MA, USA.
 
bullet point  Academic Affiliation
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2000-01 Attending: Department of Ophthalmology, Hadassah University Medical Center, Jerusalem, Israel.

2003-present: Visiting Assistant Professor, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA.

2003-09: Assistant Professor and Director, Ophthalmic Imaging Research Laboratories,
Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Pittsburgh, PA, USA

2009-present: Associate Professor and Director, Ophthalmic Imaging Research Laboratories, Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Pittsburgh, PA, USA.
 
bullet point  Publications
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Selected Publications from more than 120 peer-reviewed manuscipts

1. Garway-Heath DF, Wollstein G, Hitchings RA. Aging changes of the optic nerve head in relation to open angle glaucoma. Br J Ophthalmol 1997; 81: 480-5.
2. Wollstein G, Garway-Heath DF, Hitchings RA. Identification of early glaucoma cases with the Scanning Laser Ophthalmoscope. Ophthalmology 1998; 105: 1557-63.
3. Garway-Heath DF, Poinoosawmy D, Wollstein G, Viswanathan A, Kamal D, Fontana L, Hitchings RA. Inter- and intraobserver variation in the analysis of optic disc images: comparison of the Heidelberg retina tomograph and computer assisted planimetry. Br J Ophthalmol 1999; 83: 664-9.
4. Wollstein G, Elstein D, Strassman I, Seelenfreund M, Zylbermann R, Zimran A. Preretinal white dots in adult type Gaucher disease. Retina 1999; 19: 570-1.
5. Wollstein G. Retinal Thickness Analyzer (RTA) - the machine and its application. Harefuah 1999; 137: 562-563.
6. Rosenthal G, Wollstein G, Klemperer I, Lifshitz T. Macular changes in type I Gaucher's disease. Ophthalmic Surg Lasers 2000; 31: 331-3.
7. Wollstein G, Garway-Heath DF, Poinoosawmy D, Hitchings RA. Glaucomatous optic disc changes in the contralateral eye of unilateral normal pressure glaucoma patients. Ophthalmology 2000; 107: 2267-71.
8. Wollstein G, Garway-Heath DF, Fontana L, Hitchings RA. Identifying early glaucomatous changes: Comparison between expert clinical assessment of optic disc photographs and confocal scanning ophthalmoscopy. Ophthalmology 2000; 107: 2272-7.
9. Williams ZY, Schuman JS, Gamell L, Nemi A, Hertzmark E, Fujimoto JG, Mattox C, Simpson J, Wollstein G. Optical coherence tomography measurement of nerve fiber layer thickness and the likelihood of a visual field defect. Am J Ophthalmol 2002; 134: 538-46.
10. Guedes V, Schuman JS, Hertzmark E, Wollstein G, Correnti A, Mancini R, Lederer D, Voskanian S, Velazquez L, Pakter HM, Pedut-Kloizman T, Fujimoto JG, Mattox C. Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous eyes. Ophthalmology 2003; 110: 177-89.
11. Schuman JS, Wollstein G, Farra T, Hertzmark E, Aydin A, Fujimoto JG, Paunescu LA. Comparison of optic nerve head measurements obtained by optical coherence tomography and confocal scanning laser ophthalmoscopy. Am J Ophthalmol 2003; 135: 504-12.
12. Wollstein G, Elstein D, Zimran A. Ocular findings in adult type Gaucher disease. Haema 2003; 6: 217-21.
13. Correnti AJ, Wollstein G, Price LL, Schuman JS. Comparison of optic nerve head assessment with a digital stereoscopic optic disc camera (Discam), scanning laser ophthalmoscopy, and stereography. Ophthalmology 2003; 110: 1499-1505.
14. Aydin A, Wollstein G, Price LL, Schuman JS. Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery. Ophthalmology 2003; 110: 1506-11.
15. Aydin A, Wollstein G, Price LL, Schuman JS. Evaluating pulsatile ocular blood flow analysis, optical coherence tomography and visual field testing in glaucoma patients. Am J Ophthalmol 2003; 136: 448-53.
16. Lai E, Wollstein G, Price LL, Schuman JS. Optical coherence tomography disc assessment in optic nerves with peripapillary atrophy. Ophthal Surg Lasers & Imaging 2003; 34: 498-504.
17. Paunescu LA, Schuman JS, Price LL, Stark PC, Beaton S, Ishikawa H, Wollstein G, Fujimoto JG. Reproducibility of nerve fiber layer, macular thickness and optic nerve head measurements using Stratus OCT optical coherence tomography. Inves Ophthal Vis Sci 2004; 45: 1716-24.
18. Wollstein G, Schuman JS, Price LL, Aydin A, Paunescu LA, Beaton S, Stark PC, Fujimoto JG, Ishikawa H. Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields. Am J Ophthalmol 2004; 138: 218-25.
19. Stein DM, Wollstein G, Schuman JS. Imaging in glaucoma. Ophthalmol Clin North Am 2004; 17: 33-52.
20. Lin P, Wollstein G, Schuman JS. Contact transscleral Neodymium:YAG laser cyclophotocoagulation: long-term outcome. Ophthalmology 2004; 111: 2137-43.
21. Wollstein G, Ishikawa H, Wang J, Beaton SA, Paunescu LA, Schuman JS. Comparison of three OCT scanning areas for detection of glaucomatous damage. Am J of Ophthalmol 2005; 139: 39-43.
22. Wollstein G, Paunescu LA, Ko TH, Fujimoto JG, Kowalevicz A, Hartl I, Beaton SA, Ishikawa H, Mattox C, Singh O, Duker J, Drexler W, Schuman JS. Ultrahigh resolution optical coherence tomography in glaucoma. Ophthalmology 2005; 112: 229-37.
23. Wollstein G, Schuman JS, Price LL, Aydin A, Stark PC, Hertzmark E, Lai E, Ishikawa H, Mattox C, Fujimoto JG, Paunescu LA. Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma. Arch Ophthalmol 2005; 123: 464-70.
24. Ishikawa H, Stein DM, Wollstein G, Beaton SA, Fujimoto JG, Schuman JS. Macular segmentation with optical coherence tomography. Inves Ophthal Vis Sci 2005; 46: 2012-7.
25. Hammer DX, Ferguson RD, Magill JC, Paunescu LA, Beaton S, Ishikawa H, Wollstein G, Schuman JS. Active retinal tracker for clinical optical coherence tomography systems. J Biomed Opt. 2005; 10: 24038.
26. Ko TH, Fujimoto JG, Schuman JS, Paunescu LA, Kowalevicz AM, Hartl I, Drexler W, Wollstein G, Duker JS, Ishikawa H. Comparison of ultrahigh and standard resolution optical coherence tomography for imaging of macular pathology. Ophthalmology 2005; 112; 1922-35.
27. Burgansky-Eliash Z, Wollstein G, Chu T, Ramsey JD, Glaymour C, Noecker RJ, Schuman JS. Optical coherence tomography machine learning classifiers for glaucoma detection - a preliminary study. Inves Ophthal Vis Sci 2005; 46: 4147-52.
28. Stein DM, Ishikawa H, Hariprasad R, Wollstein G, Noecker RJ, Fujimoto J, Schuman JS. A new quality assessment parameter for optical coherence tomography. Br J Ophthalmol 2006; 90: 186-90.
29. Ishikawa H, Gabriele ML, Wollstein G, Ferguson RD, Hammer DX, Paunescu LA, Beaton SA, Schuman JS. Retinal nerve fiber layer assessment using optical coherence tomography (OCT) with active optic nerve head tracking. Inves Ophthal Vis Sci 2006; 47: 964-7.
30. Stein DM, Wollstein G, Ishikawa H, Hertzmark E, Noecker RJ, Schuman JS. The Effect of Corneal Drying on Optical Coherence Tomography (OCT). Ophthalmology 2006; 113: 985-91.
31. Kagemann L, Wollstein G, Ishikawa H, Gabriele ML, Srinivasan V, Wojtkowski M, Duker JS, Fujimoto JG, Schuman JS. Persistence of Cloquet’s Canal in Normal Healthy Eyes. Am J Ophthalmol 2006; 142: 862-4.
32. Patel A, Wollstein G, Ishikawa H, Schuman JS. Comparison of Glaucomatous Visual Field Defects Using Matrix Perimetry and Standard Achromatic Perimetry. Ophthalmology 2007; 114: 480-7.
33. Burgansky-Eliash Z, Wollstein G, Bilonick RA, Ishikawa H, Kagemann L, Schuman JS. Detecting Glaucoma with Heidelberg Retina Tomograph 3. Ophthalmology 2007; 114: 466-71.
34. Kahook MY, Noecker RJ, Ishikawa H, Wollstein G, Duker JS, FujimotoJG, Schuman JS. Peripapillary Schisis in Glaucoma Patients with Narrow Angles and Elevated Intraocular Pressure. Am J Ophthalmol 2007; 143: 697-9.
35. Wollstein R, Haimsky N, Wollstein G, Gaber S. Evaluating Short-Term Pain after Steroid Injection. Am J of Orthopedics 2007;36: 128-34.
36. Burgansky-Eliash Z, Wollstein G, Patel A, Bilonick RA, Ishikawa H, Kagemann L, Dilworth WD, Schuman JS. Glaucoma Detection with Matrix and Standard Achromatic Perimetry. Br J Ophthalmol 2007; 91: 933-8.
37. Gabriele ML, Ishikawa H, Wollstein G, Bilonick RA, Kagemann L, Wojtkowski M, Srinivasan VJ, Fujimoto JG, Duker JS, Schuman JS. Peripapillary Nerve Fiber Layer Thickness Profile Determined with High Speed, Ultrahigh Resolution Optical Coherence Tomography High-Density Scanning. Inves Ophthalmol Vis Sci 2007; 48: 3154-60.
38. Schuman JS, Pedut Kloizman T, Pakter H, Wang N, Guedes V, Huang L, Pieroth L, Scott W, Hee MR, Fujimoto JG, Ishikawa H, Bilonick RA, Kagemann L, Wollstein G. Optical Coherence Tomography and Histological Measurements of Nerve Fiber Layer Thickness in Normal and Glaucomatous Monkey Eyes. Inves Ophthalmol Vis Sci 2007; 48: 3645-54.
39. Christopoulos V, Kagemann L, Wollstein G, Ishikawa H, Gabriele ML, Woitkowski M, Srinivasan V, Fujimoto JG, Duker JS, Dhaliwal DK, SchumanJS. In Vivo Corneal High-Speed Ultrahigh Resolution Optical Coherence Tomography. Arch of Ophthalmol 2007; 125: 1027-35.
40. Kagemann L, Wollstein G, Ishikawa H, Townsend KA, Gabriele ML, Sirinivasan VJ, Wojtkowski M, Fujimito JG, Schuman JS. Spectral Oximtery Assessed with High Speed Ultra-High Resolution Optical Coherence Tomography. J Biomed Opt 2007; 12: 041212 1-8.
41. Xu J, Ishikawa H, Wollstein G, Schuman JS. Translation Histogram Based Hierarchial Algorithm for 3-D Optic Nerve Head Modeling. Conf Proc IEEE Eng Med Biol Soc. 2007; 1: 6751-4.
42. Manassakorn A, Ishikawa H, Kim JS, Wollstein G, Bilonick RA, Kagemann L, Gabriele M, Sung KR, Mumcuoglu T, Duker JS, Fugimoto JG, Schuman JS. Comparison of Optic Disc Margin Identified by Planimetry and High Speed Ultra-high Resolution Optical Coherence Tomography. Arch of Ophthalmol 2008; 126: 58-64.
43. Gabriele ML, Wollstein G, Bilonick RA, Burgansky-Eliash Z, Ishikawa H, Kagemann LE, Schuman JS. Comparison of Parameters from Heidelberg Retina Tomograph 2 and 3. Ophthalmology 2008; 115: 673-7.
44. Mumcuoglu T, Wollstein G, Wojtkowski M, Kagemann L, Ishikawa H, Gabriele ML, Sirinvasan V, Fujimoto JG, Duker JS, Schuman JS. Improved Visualization of Glaucomatous Retinal Damage Using High-Speed, Ultrahigh-Resolution OCT. Ophthalmology 2008; 115: 782-9.
45. Gabriele ML, Ishikawa H, Wollstein G, Bilonick RA, Townsend KA, Kagemann L, Wojtkowski M, Srinivasan VJ, Fujimoto JG, Duker JS, Schuman JS. Optical Coherence Tomography Scan Circle Location and Mean Retinal Nerve Fiber Layer Measurement Variability. Inves Ophthalmol Vis Sci 2008; 49: 2315-21.
46. Xu J, Ishikawa H, Wollstein G, Bilonick RA, Sung KR, Kagemann L, Schuman JS. Automated Assessment of Optic Nerve Head on Stereo Disc Photographs. Inves Ophthalmol Vis Sci 2008; 49: 2512-17.
47. Townsend KA, Wollstein G, Schuman JS. Clinical application of magnetic resonance imaging in ophthalmology. NMR Biomed 2008; 21: 997-1002.
48. Kagemann L, Mumcuoglu T, Wollstein G, Bilonick RA, Ishikawa H, Townsend KA, Gabriele ML, Dilworth W, Fujimoto JG, Schuman JS. Sources of Longitudinal Variability in Optical Coherence Tomography Nerve Fiber Layer Measurements. Br J Ophthalmol 2008; 92: 806-9.
49. Townsend KA, Wollstein G, Danks D, Sung KR, Ishikawa H, Kagemann L, Gabriele ML, Schuman JS. Heidelberg Retina Tomography III Machine Learning Classifiers for Glaucoma Detection. Br J Ophthalmol 2008; 92: 814-8.
50. Kagemann L, Ishikawa H, Wollstein G, Brenne P, Townsend KA, Gabriele ML, Schuman JS. Ultrahigh Resolution Spectral Domain Optical Coherence Tomography Imaging of the Lamina Cribrosa. Ophthal Surg Las Imag 2008; 39: S126-131.
51. Mumcuoglu T, Townsend KA, Wollstein G, Ishikawa H, Bilonick RA, Sung KR, Kagemann L, Schuman JS, Advanced Imaging in Glaucoma Study Group. Assessing the Relationship between Central Corneal Thickness and Retinal Nerve Fiber Layer Thickness in Healthy Subjects. Am J Ophthalmol 2008; 146: 561-6.
52. Kagemann L, Ishikawa H, Zou J, Charukamnoetkanok P, Wollstein G, Townsend KA, Gabriele ML, Bahary N, Wie X, Fujimoto JG, Schuman JS. Repeated, Noninvasive, High Resolution Spectral Domain Optical Coherence Tomography Imaging of Zebrafish Embryos. Mol Vis 2008; 14: 2157-70.
53. Xu J, Ishikawa H, Wollstein G, Schuman JS. Retinal Vessel Segmentation on SLO Image. Conf Proc IEEE Eng Med Biol Soc. 2008; 1: 2258-61.
54. Kagemann L, Wollstein G, Ishikawa H, Townsend KA, Schuman JS. Validation of Spectral Domain Optical Coherence Tomographic Doppler Shifts Using an In-Vitro Flow Model. Inves Ophthalmol Vis Sci 2009; 50: 702-6.
55. Kagemann L, Ishikawa H, Wollstein G, Gabriele M, Schuman JS. Visualization of 3-D High Speed Ultrahigh Resolution Optical Coherence Tomographic Data Identifies Structures Visible in 2D Frames. Opt Express. 2009; 17: 4208-20.
56. Ishikawa H, Kim JS, Friberg TR, Wollstein G, Kagemann L, Gabriele ML, Townsend KA, Sung KR, Duker JS, Fujimoto JG, Schuman JS. Three Dimensional Optical Coherence Tomography (3D-OCT) Image Enhancement with Segmentation Free Contour Modeling C-Mode. Inves Ophthalmol Vis Sci 2009; 50: 1344-9.
57. Ricco S, Chen M, Ishikawa H, Wollstein G, Schuman J. Correcting Motion Artifacts in Retinal Spectral Domain Optical Coherence Tomography via Image Registration. Med Image Comput Comput Assist Interv 2009; 12: 100-7.
58. Townsend KA, Wollstein G, Schuman JS. Imaging of the retinal nerve fiber layer for glaucoma. Br J Ophthalmol 2009; 93: 139-43.
59. Sung KR, Wollstein G, Bilonick RA, Townsend KA, Ishikawa H, Kagemann L, Noecker RJ, Fujimoto JG, Schuman JS. Effects of Age on Optical Coherence Tomography Measurements of Healthy Retinal Nerve Fiber Layer, Macula and Optic Nerve Head. Ophthalmology 2009; 116: 1119-24.
60. Kim JS, Ishikawa H, Sung KR, Xu J, Wollstein G, Bilonick RA, Kagemann L, Duker JS, Fujimoto JG, Schuman JS. Retinal Nerve Fiber Layer Thickness Measurement Reproducibility Improved with Spectral Domain Optical Coherence Tomography. Br J Ophthalmol 2009; 93: 1057-63.
61. Sung KR, Wollstein G, Schuman JS, Bilonick RA, Ishikawa H, Townsend KA, Kagemann L, Gabriele ML; Advanced Imaging in Glaucoma Study Group. Scan quality effect on glaucoma discrimination by glaucoma imaging devices. Br J Ophthalmol. 2009; 93: 1580-4.
62. Pantcheva MB, Wollstein G, Ishikawa H, Noecker RJ, Schuman JS. Optical Coherence Tomography Algorithm Failure To Detect Nerve Fiber Layer Defects: A Case Series. Br J of Ophthalmol 2009; 93: 1141-2.
63. Kim JS, Ishikawa H, Gabriele ML, Wollstein G, Bilonick RA, Kagemann L, Fujimoto JG, Schuman JS. Retinal nerve fiber layer thickness measurement comparability between time domain optical coherence tomography (OCT) and spectral domain OCT. Invest Ophthalmol Vis Sci. 2010; 51: 896-902.
64. Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, Varma R, Huang D. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology. 2009; 116: 2305-14. e1-2.
65. Kagemann L, Wollstein G, Ishikawa H, Bilonick RA, Brennen PM, Folio LS, Gabriele ML, Schuman JS. Identification and Assessment of Schlemm's Canal by Spectral Domain Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2010; 51: 4054-9.
66. Xu J, Ishikawa H, Wollstein G, Bilonick RA, Kagemann L, Craig JE, Mackey DA, Hewitt AW, Schuman JS. Automated volumetric evaluation of stereoscopic disc photography. Opt Express. 2010; 18: 11347-59.
67. Liu YY, Chen M, Ishikawa H, Wollstein G, Schuman JS, Rehg JM. Automated macular pathology diagnosis in retinal OCT images using multi-scale spatial pyramid with local binary patterns. Med Image Comput Comput Assist Interv. 2010; 13: 1-9.
68. Gabriele ML, Wollstein G, Ishikawa H, Xu J, Kim J, Kagemann L, Folio LS, Schuman JS. Three dimensional optical coherence tomography imaging: Advantages and advances. Prog Retin Eye Res 2010; 29: 556-79.
69. Fine JL, Kagemann L, Wollstein G, Ishikawa H, Schuman JS. No More Glass: Direct Scanning of Pathology Specimens Using Spectral Domain Optical Coherence Tomography (A Pilot Study). Ophthal Surg Las Imag (In press).
70. Gabriele ML, Ishikawa H, Schuman JS, Bilonick RA, Kim JS, Kagemann L, Wollstein G. Reproducibility of Spectral-Domain Optical Coherence Tomography Total Retinal Thickness Measurements in Mice. Invest Ophthalmol Vis Sci (In press).
71. Sung KR, Kim JS, Wollstein G, Folio L, Kook MS, Schuman JS. Imaging of the Retinal Nerve Fiber Layer with Spectral Domain Optical Coherence Tomography for Glaucoma Diagnosis. Br J Ophthalmol (In press).
72. Gabriele ML, Ishikawa H, Schuman JS, Lin Y, Bilonick RA, McKenna KC, Kim JS, Kagemann L, Wollstein G. Optic Nerve Crushed Mice Followed Longitudinally with Spectral Domain Optical Coherence Tomography. Inves Ophthalmol Vis Sci (In press).
73. Gabriele ML, Wollstein G, Ishikawa H, Kagemann L, Xu J, Folio LS, Schuman JS. Optical coherence tomography: history, current status and laboratory work. Inves Ophthalmol Vis Sci (In press).
 
bullet point  Grants
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IIsrael Medical Association Fellowship Scholarship.

American Physician Fellowship for Medicine in Israel.

RAND Institute

National Institute of Health
 
 
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